Development of microsecond magnetic pulse generators for cell membrane permeabilization control

Gediminas Staigvila

Doctoral dissertation

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The dissertation deals with magnetic field pulse generators and technologies for controlling the plasma membrane permeability of cells. In this work, pulse inductors were used as a load, the work, and attempted contactlessly induce reversible and irreversible changes in biological objects, by magnetic field pulses of different shapes and parameters.

The dissertation consists of an introduction, three chapters, general conclusions, references and lists of the author's publications on the topic of the dissertation.

The introductory chapter discusses the research problem, the relevance of the work, describes the object of research, formulates the aim and objectives of the work, describes the research methodology, scientific novelty, the practical significance of results, defended statements. At the end of the introduction, the author's publications and conference papers on the topic of the dissertation and the structure of the dissertation are presented.

The first chapter is devoted to a review of the literature. It presents the principles of operation and application of various generator circuits. At the end of the chapter, conclusions are formulated and the tasks of the dissertation are specified.

The second chapter describes the three developed magnetic field generators and working principle of separate circuits.

The third chapter presents the results of inductor simulation models, the parameters of the induced electric field and the results of applied experiments with different cell types.

On the topic of the dissertation 5 articles were published: four in scientific journals included in the Clarivate Analytics Web of Science list with impact factor, and one in conference proceedings included in the Clarivate Analytics Web of Science database. 8 presentations on the topic of the dissertation were read at national and international conferences.

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94 p.
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